GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs683250 | 1 | rs505621 | chr11:83277927 | CCDC90B | chr11:82972506-82997414:- | 0.17 | 4.05 | 5.96E-5 | Subcortical brain region volumes |
| THCA | cis | rs683250 | 1 | rs505998 | chr11:83315597 | CCDC90B | chr11:82972506-82997414:- | 0.16 | 3.77 | 0.000182 | Subcortical brain region volumes |
| THCA | cis | rs477692 | 1 | rs506274 | chr10:131409392 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.43 | 6.49E-27 | Response to temozolomide |
| THCA | cis | rs507080 | 1 | rs507080 | chr11:118549582 | TREH | chr11:118528942-118550381:- | 0.48 | 9.57 | 5.97E-20 | Serum metabolite levels |
| THCA | cis | rs477692 | 1 | rs508303 | chr10:131424996 | MGMT | chr10:131265454-131565783:+ | -0.37 | -11.24 | 3.62E-26 | Response to temozolomide |
| THCA | cis | rs508970 | 1 | rs508970 | chr11:60906450 | CD5 | chr11:60869930-60895321:+ | -0.09 | -3.63 | 0.000314 | Rheumatoid arthritis |
| THCA | cis | rs508970 | 1 | rs508970 | chr11:60906450 | PGA3 | chr11:60970984-60993916:+ | 0.19 | 3.41 | 0.000706 | Rheumatoid arthritis |
| THCA | cis | rs7112513 | 1 | rs510988 | chr11:116813804 | PCSK7 | chr11:117075789-117102811:- | -0.28 | -4.77 | 2.43E-6 | Protein quantitative trait loci |
| THCA | cis | rs7112513 | 1 | rs511676 | chr11:116824884 | PCSK7 | chr11:117075789-117102811:- | -0.26 | -4.57 | 6.15E-6 | Protein quantitative trait loci |
| THCA | cis | rs1171113 | 1 | rs512140 | chr6:84230653 | SNAP91 | chr6:84262607-84419127:- | 0.2 | 4 | 7.25E-5 | Bipolar disorder with mood-incongruent psychosis |
| THCA | cis | rs477692 | 1 | rs513736 | chr10:131406489 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.31 | 1.85E-26 | Response to temozolomide |
| THCA | cis | rs800292 | 1 | rs514591 | chr1:196640320 | CFHR3 | chr1:196743930-196762872:+ | 0.24 | 4.66 | 4.04E-6 | Circulating myeloperoxidase levels (serum) |
| THCA | cis | rs516946 | 1 | rs515071 | chr8:41519462 | ANK1 | chr8:41510745-41754280:- | -0.22 | -4.65 | 4.21E-6 | Type 2 diabetes |
| THCA | cis | rs515910 | 1 | rs515910 | chr10:105966404 | C10orf79 | chr10:105889647-105992120:- | 0.25 | 8.01 | 8.87E-15 | Attention deficit hyperactivity disorder |
| THCA | cis | rs477692 | 1 | rs516704 | chr10:131419879 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.47 | 4.34E-27 | Response to temozolomide |